Nonfiction: reportage or analysis.
Most of the early scientific practices rooted in alchemy are based on the belief that one must taste, touch, see, feel, hear and smell a tangible result--and be able to duplicate it--rather than take the results for granted.
Who can do alchemy? If alchemy is a route to understanding/embracing one's own godhood, do all humans have such godhead potential as a state of being human?
Our history has produced mechanical science as its primary tool for technological advancement; the FMA history produced alchemy to the same ends.
There's a bit of a debate in classics over whether or not the Fates are the supreme beings of the world, whose power cannot be trumped even by Zeus, King of the gods.